Matthew A. Ciorba, MD

Principal Investigator

Our research group is inspired by the challenges endured by patients affected by colon cancer and the inflammatory bowel diseases (IBD) including Crohn’s disease and Ulcerative Colitis.  Our guiding goal is to make discoveries that will ultimately enhance quality-of-life for individuals affected by gastrointestinal cancer and intestinal inflammation. To achieve this goal, we are investigating novel ways to therapeutically target disease-related dysfunction of the gut epithelium.

Our research program thrives at the interface of cutting-edge science and personalized medicine.  We use innovative basic-translational research approaches and actively engage with the robust clinical programs at WUSM to foster Bench to Bedside collaboration and discovery. Key techniques include human and murine epithelial stem cell culture (organoids), metabolomics, and microbial profiling molecular biology and genetic engineering, assays on tissue samples from patients with IBD and colon cancer as well as murine modeling of IBD and colon cancer.

Medical Education​

B.S. Exercise Science, University of Iowa College of Liberal Arts, Iowa City, Iowa, 1996
M.D. Univ. of Iowa College of Medicine, Iowa City, Iowa, 2001
Residency: Internal Medicine, Washington University SOM, St. Louis, Missouri, 2004
Fellowship: Gastroenterology, Washington University SOM, St. Louis, Missouri, 2007
IBD clinical fellowship: Mount Sinai Hospital in New York City 2007​


2007-2010 – Instructor of Medicine
2008-2010 – Director, Inflammatory Bowel Diseases Clinical Fellowship
2010-2017 – Assistant Professor of Medicine
2016-present – Director of Research, Inflammatory Bowel Disease Center
2016-present – Associate Director of GI Fellowship Program and Fellow Research (T32)
2017-present – Associate Professor of Medicine
2017-present – Director, Inflammatory Bowel Disease Center

Scientific Review Committees

Editorial Board: Journal of Clinical Gastroenterology, Translational Research

Reviewer (Ad hoc): Journal of Clinical Investigation, Journal of Immunology, AGA Journals [Gastroenterology, Cellular and Molecular Gastroenterology and Hepatology, Clinical Gastroenterology and Hepatology], Inflammatory Bowel Diseases Journal, Journal of Crohn’s and Colitis, American Journal of Pathology, British Journal of Pharmacology, Journal of Gastroenterology and Hepatology, Digestive Diseases and Sciences, Radiation Research, Journal of Basic Microbiology, Hospital Practice, American Journal of Clinical Nutrition, Nature Scientific Reports, etc.

Funding Agency Review Committees: Longer Life Foundation, NSPIRES: NASA Scientific Awards, Department of Defense: USAMRMC/CDMRP Scientific Awards, The Swedish Foundation for Strategic Research, Welcome Trust, NIDDK, Marsden Fund of the Royal Society of New Zealand, Broad Foundation

Professional Society Service

2003-Present   American Gastroenterology Association: Education and Training Committee, Continuing Medical Education Oversight Subcommittee, Research Awards Committee, Scientific Abstract Review Committee.

2006-Present Crohn’s and Colitis Foundation: Medical Advisory Committee for Mid-America Chapter, Research Awards Committee

2017-Present American College of Gastroenterology